WHAT IS
LIPOATROPHY?
LIPOATROPHY is a focal loss of subcutaneous fat with
variable overlying skin changes and depth depending on the cause.
DIFFERENCE
BETWEEN LIPOATROPHY AND LIPODYSTROPHY?
LIPODYSTROPHY is abnormal fat distribution including both
lipohypertrophy (fat accumulation) and lipoatrophy (fat wasting or loss), the body is unable to produce and
maintain healthy fat tissue.
LIPOATROPHY
: usually used when describing the loss of fat from one
area
WHAT ARE INJECTIONS WHICH MAY CAUSE LOCALIZED
LIPOATROPHY ?
Most
common
Insulin
• Non-human ≫ human, insulin analogues
• Rarely, can occur at distant sites
Corticosteroids
• Non-human ≫ human, insulin analogues
• Rarely, can occur at distant sites
Corticosteroids
Less
common
Antibiotics
• Benzathine penicillin
• Amikacin
Immunomodulatory drugs
• Glatiramer acetate (multiple sclerosis)
• Methotrexate
Vaccines
• Diphtheria–pertussis–tetanus vaccine
• Quadrivalent human papillomavirus vaccine
Growth hormone
Heparin
Iron dextran
Exogenous material
• Benzathine penicillin
• Amikacin
Immunomodulatory drugs
• Glatiramer acetate (multiple sclerosis)
• Methotrexate
Vaccines
• Diphtheria–pertussis–tetanus vaccine
• Quadrivalent human papillomavirus vaccine
Growth hormone
Heparin
Iron dextran
Exogenous material
HOW TO TREAT
STEROID INDUCED LIPOATROPHY?
Serial
saline injections on a weekly basis are found to completely resolve the
cosmetic effect of lipoatrophy within 4 to 8 weeks of the initial saline
injection.
NORMAL SALINE MECHANISM OF ACTION IN STEROID INDUCED
LIPOATROPHY?
Injecting
saline where steroid crystals lie would put them back into suspension, where
the crystals could then be recognized as foreign bodies and naturally removed
from the body
References
:
1- Dermatology, 4th Edition
3-
Margulies, S. L., & Morris, A. (2015).
Successful treatment of lipoatrophy with normal saline. JAAD case reports, 1(6), 415–417. doi:10.1016/j.jdcr.2015.10.008
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